SCN8A and ocular hypertension: Similar to our results, NaV1.6 immunolabelling is also reduced in optic nerve axons of experimental models of diseases that cause axon demyelination.31,32 In both acute and genetic models, demyelination induces the substitution of NaV1.6 for NaV subunit 1.2 (NaV1.2).31,32 Therefore, we determined if unilateral ocular hypertension or optic nerve crush altered the accumulation of NaV1.2 in optic nerve axon nodes of Ranvier.