At present, quadruple therapy is the primary way to treat Hp infection-related diseases, in which the dual-use of antibiotics can enhance the antibacterial effect, which is beneficial to inhibiting the proliferation of Hp; proton pump inhibitor (PPI) can reduce gastric mucosal damage by inhibiting gastric acid secretion; bismuth is a mucosal protective agent, which is a crucial drug to promote ulcer healing [5]. The gene discussed is HP; the disease is ulcer disease.