The model involved CFB, MAL2, PSME2, MRPL13, HMGB3, DCTPP1, SHCBP1, SLC35A2, and EVA1B, of which CFB, PSME2, and EVA1B were used as cancer prognostic protective factors, and the remaining genes were used as prognostic risk factors. This evidence concerns the gene HMGB3 and cancer.