Among these eight genes, the expression of CHGA, CLU, GCG, and AJUBA were negatively correlated with the overall survival of patients with CRC and were poor prognostic factors, and the expression of PLK1, AXIN2, NR3C2, and IL17RB were positively correlated with the prognosis of patients with CRC and were thus favorable prognostic factors. The gene discussed is AJUBA; the disease is colorectal carcinoma.