And when PB ATM mRNA determined by PCR was <2.26, the sensitivity and specificity for diagnosing ESCC were 67.14% and 70.18%, respectively (AUC = 0.7480, 95%CI = 0.6597 − 0.8363, P < 0.001, Figure 2(b)). This evidence concerns the gene ATM and esophageal squamous cell carcinoma.