Furthermore, Shugan Hewei Decoction containing Chai Hu (Bupleuri radix), Huang Lian (Coptis chinensis) and Gan Cao (Glycyrrhiza uralensis) has been reported to help manage anxiety and depression in chronic stress model rats by suppressing the NLRP3 inflammasome and cecal microbiota (Yue et al., 2021). Here, NLRP3 is linked to major depressive disorder.