1,25(OH)2D3 is known to inhibit NF-κB activation by forming VDR-p65 complex, increases the level of IκBα (Cohen-Lahav et al., 2006), or strengthens the interaction between VDR and IKKβ (Chen et al., 2013), thereby restraining inflammation and tumor growth (Tan et al., 2008). The gene discussed is VDR; the disease is neoplasm.