Accumulating evidence has also shown that the repression of TGF-β1-induced activation of mTOR signaling in lung fibroblasts, which results in the induction of autophagy and the inhibition of myofibroblast activation and ECM production in mice model of BLM-induced pulmonary fibrosis (Li et al., 2021; Lu et al., 2022). This evidence concerns the gene MTOR and pulmonary fibrosis.