BCL2 and Familial prostate cancer: In various examples of human cancer lines such as prostate cancer, myeloid leukemia, breast cancer, glioblastoma etc., it has been demonstrated that they have heighten expression of multiple anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL and Mcl-1) and have displayed strong chemo resistance (Wei et al., 2011; Sadahira et al., 2014; Vogler, 2014; Correia et al., 2015; Gong et al., 2016; Frame et al., 2020).