The pathologic role of MMP-12 has been demonstrated in a variety of neurologic diseases, including hemorrhagic stroke, spinal cord injury (SCI), and other pathologies (Power et al., 2003; Wells et al., 2003, 2005; Veeravalli et al., 2009; Chelluboina et al., 2018). This evidence concerns the gene MMP12 and hemorrhagic stroke.