Transcriptional networks linked to later stages of pancreatic development and differentiation. Upregulated transcription factors (NR5A2, MIST1 and RBPJL) involved in acinar cell differentiation and regeneration after pancreatitis. Activated genes linked to endo crine differentiation and MODY diabetes, Exocrine secretion and regulation of beta cell development. The gene discussed is RBPJL; the disease is pancreatitis.