Firstly, compared with other non‐interventional AS cohorts, we permitted a higher PSA inclusion threshold (≤15 ng/ml),15 leading to a higher baseline PSA (median 7.2 ng/ml),24 and observed a higher proportion of ISUP grade group 2 tumours (20.4% vs. 14.5%).24 This evidence concerns the gene KLK3 and neoplasm.