Finally, M7824, a bifunctional fusion protein containing an extracellular TGFβRII domain and antibody against PD-L1, localizes to tumour microenvironments, sequesters TGFβ ligands, and stimulates T-cell immune activity (Figure 13) (Knudson et al., 2018; Paz-Ares et al., 2018; Lind et al., 2020). This evidence concerns the gene TGFB1 and neoplasm.