REN and renal artery disease: Uric acid accumulation in the kidney can activate renin-angiotensin inhibit epithelial-mesenchymal transdifferentiation, nitric oxide synthase-aldosterone system, trigger an inflammatory response, oxidative stress, etc., and eventually lead to tubulointerstitial damage and renal vascular disease, which is also an important reason for the exacerbation of CKD [10].