For example, two tumour-inducing genes such as ferroportin (FPN) and lipocalin2 (LCN2) were knockdown by Cas13a/U6-gRNA with a NF-ĸβ expression controlled “minimal decay promoter” (DMP) (Fig. 10a and b), coated with magnetite nanocarrier that significantly enhanced the ferroptosis in MDA-MB-453 ​cells line (Fig. 10c). Here, SLC40A1 is linked to neoplasm.