HDAC5 and neoplasm: In addition to this, HDAC5 in class II HDACs combined with vascular endothelial growth factor (VEGF) is involved in tumor angiogenesis, and the PKD-dependent phosphorylation-specific deletion of HDAC5 inhibits VEGF-mediated expression of an oligomeric nuclear receptor (RN4A1), endothelial cell migration, and angiogenesis in vitro [23].