Several chemotherapeutic drugs initiate caspase‐3‐induced apoptosis to kill cancer cells, which also lays the foundation for mediating the pyroptosis process based on GSDME (originally translated by DFNA5).[45] However, most cancer cells lack the critical protein GSDME for caspase‐3‐derived cell pyroptosis, which is attributed to DFNA5 gene hypermethylation. The gene discussed is GSDME; the disease is cancer.