GSDME and melanoma: Bax was brought into the mitochondria to aid in the release of cytochrome c for caspase‐9 and caspase‐3 activation, which subsequently led to pyroptotic death through the cleavage of GSDME (Figure7a).[31] After CDT was monitored, cells resembled the typical pyroptotic cell shape with visible balloon‐like bubbles, whereas melanoma cells demonstrated the typical apoptotic morphology upon GSDME knockdown (Figure 7b).