GAST and neoplasm: On this basis, the gastrin and NHSDY647‐PEG1 modified magnetic iron oxide nanoparticles (Gastrin‐MNPs) were developed to be specifically internalized by tumor cells and subsequently gathered into lysosomes to cause nonapoptotic cell death upon the AMF.[23] The lysosome‐accumulated MNPs could increase the temperature very locally and promote cytotoxic free radical generation, which induced lipid peroxidation, lysosome membrane permeabilization, and leakage of lysosomal enzymes into the cytoplasm (Figure4a).