GSDMD and cancer: Inspired by this, the liposome‐encapsulated MOFs (Lip‐MOF) were designed as pyroptotic inducers consisting of 1,2‐dileoyl‐snglycero‐3‐phosphocholine (DOPC) loading Fe3+ and trimesic acid‐based MOFs (Figure9a).[36] The Lip‐MOF was readily endocytosed by cancer cells and released Fe3+ with the help of acidic conditions, which subsequently activated the caspase to cleave GSDMD into GSDMD‐N fragments for cancer cell pyroptosis (Figure 9b).