The expression of GSDM‐proteins is downregulated in different cancer cells, and these proteins are unraveled to possess antitumor pyroptosis properties.[63] Consequently, the upregulation of GSDM‐proteins expression could activate cascade pyroptosis in tumor cells.[64] The purified GSDM‐A3 protein conjugated to gold nanoparticles (GSDMA‐NP) was designed and developed via the triethylsilyl ether linkage.[65] The phenylalanine trifluoroborate (Phe‐BF3) was introduced to cleave the ether linkage for the liberation of GSDM‐A3 from the designed GSDMA‐NP (Figure21a). Here, GSDMA is linked to neoplasm.