APEX1 and lung cancer: GOS is a unique secondary metabolite of Gossypium plant that has a variety of pharmacological effects.[60, 61, 62] In China, GOS is available as a prescription drug for the treatment of gynecological diseases[63] and is under phase III clinical trial as an adjuvant drug for the treatment of advanced non‐small cell lung cancer with high apurinic/apyrimidinic endonuclease 1 (APE1) expression (NCT number: NCT01977209).