HPGDS and cancer: GSTs can catalyze the binding of GSH and many anticancer drugs, which are substrates for GSTs and extruded from cells efficiently.35, 36, 37 In some cancers, the detoxifying activity of GSTs still play an important role in drug resistance via activating the GST/GSH cellular system.6, 35 Additionally, enhance GSTP1 gene expression or protein level, or both seem to be related with increased GSTpi enzymatic activity.