It can disrupt the interaction between the GSTpi‐ TRAF2 and GSTpi‐ JNK to induce apoptosis, and avoid extrusion from cancer cells by export pumps.10, 11, 18, 19 Additionally, a recent study demonstrates that NBDHEX acts as late‐phase autophagy inhibitor, opening its new therapeutic opportunities.20 We summarized its satisfactory anticancer ability in various animal models and cancer cell lines previously, including acute myeloid leukemia, small cell lung cancer, osteosarcoma, and so on.21 However, the role of NBDHEX on GSTpi in ADR‐resistance breast cancer remains unexplored. This evidence concerns the gene MAPK8 and cancer.