IL18 and acute respiratory distress syndrome: To explore the effects of GSDMD on LPS-induced pyroptosis in the lung of ALI and ALI-induced intestinal mucosal dysfunction, we found that the pyroptosis inflammatory factors, IL-1β and IL-18 were increased in the serum and lung tissue of WT-LPS group, and Gsdmd deficiency reversed the high expression (Fig. 4 A&B).