A study showed that DSF combined with Cu was shown to be a underlying inhibitor of the functional proteasomes by activation of NF-κB pathway, where proteasomes are involved in degradation of the inhibitor-KB molecule (IkB) in many cancers [29, 30].Other studies have indicated that disulfiram can inhibit inflammation and fibrosis in renal fibrosis rats and unilateral unilateral obstruction model by inhibiting GSDMD[31]. The gene discussed is NFKB1; the disease is renal fibrosis.