In contrast, there was down-regulation of these four genes in Kidney Chromophobe (KICH), Kidney renal clear cell carcinoma (KIRC), and Thyroid carcinoma Compared to METTL8, the other three genes (METTL2A, METTL2B and METTL6) exhibited a more homogenized co-expression in various cancer types. The gene discussed is METTL8; the disease is thyroid gland carcinoma.