Aside from the classical m3C32 modification of mitochondrial tRNAs, upregulated of METTL8 by Yin Yang 1 (YY1) transcription factor mediated the m3C modification on the mRNA of AT-rich interactive domain-containing protein 1A and attenuated its translation, which induced the migration of breast cancer cell lines [17]. The gene discussed is YY1; the disease is breast cancer.