It is interesting that, the expressions of MYBL2, CSE1L, and most neighbors of NAE1 (59/63) are significantly different between tumor and normal tissues (P-value < 0.05, Wilcoxon rank sum test with continuity correction), but as a link gene NAE1 is not differentially expressed (see Fig. 6B). The gene discussed is NAE1; the disease is neoplasm.