CASP3 and breast carcinoma: CASP3 is a hub gene in the mutation driver module for breast cancer, which is involved in the signaling pathways of apoptosis, necrosis, and inflammation [31]. Some studies have shown that the down-regulated expression of CASP3 could represent an important cell survival mechanism in breast cancer and overexpression in breast cancer cells exerts an independent adverse effect on patients' overall survival [32].