As an example, Fig. 1 shows the voxel-based color tumor Ktrans (left panels) and τi (right panels) parametric maps on a single image slice for a patient with breast cancer recurrence (48 years old, grade 3 invasive ductal carcinoma, ER-, PR+, HER2-, RCB = III) and a patient without recurrence (39 years old, grade 2 invasive ductal carcinoma, ER+, PR+, HER2+, RCB = 0 (pathologic complete response)) at V1 (top row) and V4 (bottom row). The gene discussed is ESR1; the disease is breast cancer.