The scatterplot of KRAS VAFs between tumor samples prepared by bulk, coring, and LMD showed that cored tumor tissues were most similar to the bulk tumor (R = 0.94, Fig. 5A), while tumor tissues prepared by LMD showed less similarity to bulk (R = 0.73, Fig. 5B) or cored tissues (R = 0.75, Fig. 5C). This evidence concerns the gene KRAS and neoplasm.