The increased scores of KRAS VAF in cored samples from C3L-0132 and C3L-01160 indicate that an enrichment of neoplastic purity near 100% can be achieved from bulk tumors containing high neoplastic cellularity by the coring technique, whereas, the KRAS VAF remained low in the other cored tumor samples from bulk tumors containing lower neoplastic cellularity. This evidence concerns the gene KRAS and neoplasm.