Based on the 348 DE-IRGs, we built a PPI network and obtained eight hub genes using MCODE analysis, including FPR2, RASGRP1, LTBR, ACKR1, PTGS2, JUN, TNFRSF1A, and CYLD to explore the regulatory networks and crucial pathways underlying CHD. The gene discussed is CYLD; the disease is coronary artery disorder.