In addition, oxaliplatin causes depolymerization of actin in sinusoidal epithelial cells and the upregulation of matrix metalloproteinases-2,9 which leads to fibroblast proliferation and endothelial cell loss as well as fibrosis of sinusoids and central veins, resulting in portal hypertension [1, 10–13]. The gene discussed is MMP2; the disease is portal hypertension.