Among others, the mutations involved in the DNA methylation (ASXL1, TET2, DNMT3A, IDH1, IDH2), histone modification (EZH2, ASXL1), and splicing (SF3B1, SRSF2, U2AF1, and ZRSR2), and mutations in the transcription factors genes (RUNX1, NFE2, PPM1D, and TP53) are most frequently found in ET pts [71, 72]. The gene discussed is SRSF2; the disease is essential thrombocythemia.