CXCL8 and primary myelofibrosis: One of the consequences is bone marrow fibrosis associated with an increased level of interleukin 8 (IL-8), oncostatin-M, lipocalin-2, transforming growth factor β1, platelet derived growth factor (PDGF), fibroblast growth factor (FGF), venous endothelial growth factor (VEGF), and inhibitors of matrix metalloproteinases in the peripheral blood [19–21].