To verify whether the upregulated CXCR4 (the chemokine with the most obviously different expression after intra‐amniotic BMSC transplantation) in the amniotic fluid played a role in the lesion‐specific migration of BMSCs, we injected CXCR4 inhibitor + BMSCs into the amniotic fluid of ex vivo cultured NTD embryos. Here, CXCR4 is linked to neural tube defect.