CNTF and amyotrophic lateral sclerosis: Local application of CNTF in the model of motoneuron diseases (such as amyotrophic lateral sclerosis) rescues loss of synaptic vesicles from the active zones of motor axon terminals to maintain the synaptic function,53 and systemic CNTF treatment in a progressive motor neuronopathy mice model could protect survival and inhibit axon loss.54