Here, an hiPSC-based model was used to explore the cell-type-specific and diagnosis-dependent glucocorticoid treatment responses of PBMCs and NGN2-glutamatergic neurons derived from male combat-exposed PTSD cases (n = 19 hiPSC donors and n = 20 PBMC donors) and controls (n = 20 hiPSC donors and n = 20 PBMC donors). This evidence concerns the gene NEUROG2 and post-traumatic stress disorder.