Likewise, in prostate cancer cells, activation of androgen receptors mediates the increased transcription of the target gene by following the serial activation of the androgen receptor, monoamine oxidase LSD1, H3K4me2 demethylation, H2O2 production, local 8-oxo-dG oxidation, OGG1-APE1 recruitment, and transcription of androgen-induced target genes, including miRNAs (e.g., KLK3, TMPRSS2, miR-125b2, and miR-133b)100. This evidence concerns the gene AR and Familial prostate cancer.