Nahari et al. evaluating legions establishment and growth in experimentally-induced endometriosis in 12 rats after 28 days of oral administration of silymarin showed that the combination of enhancing ERK1/2 expression and suppressing the Bcl-2 expression by silymarin accompanying with down-regulating the angiogenesis ratio led to promote the apoptosis pathway, consequently induced severe fibrosis in endometriotic-like legions19. This evidence concerns the gene MAPK3 and endometriosis.