In line with this and our earlier findings demonstrating the necessity of IL-6, all three inhibitors abrogated the ability of EVsMMA-MRC5 to induce IL-6/JAK/STAT3 and TGFβ signaling in A549 tumor cells, along with EMT (Fig. 4g, h, Fig. s6f, g). This evidence concerns the gene STAT3 and neoplasm.