Notably, IKK inhibition had a greater effect than both TGFβR inhibition or TAK1 inhibition in reducing IL-6 loading into EVsMMA-MRC5, which also corresponded with a greater effect in suppressing the potency of EVsMMA-MRC5 for promoting EMT and drug resistance in A549 tumor cells (Fig. 4f–i). This evidence concerns the gene IL6 and neoplasm.