In humans, TET2 loss-of-function mutations are frequent in clonal hematopoiesis (a premalignant syndrome)13–15 and a variety of haematopoietic malignancies, including diffuse large B cell lymphoma (DLBCL)16–18, peripheral T cell lymphoma (PTCL) and angioimmunoblastic T cell lymphoma (AITL)19–23, and myeloid malignancies including myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPN), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML)24–30. This evidence concerns the gene TET2 and myeloid neoplasm.