As expected, METTL3 overexpression by METTL3 gRNAs caused more AML cells to enter the cell division cycle (Supplementary Fig. S2B, C), which was consistent with the findings in a previous report [27] and suggested that METTL3 enhanced the proliferation of AML cells without chemotherapy treatment. Here, METTL3 is linked to acute myeloid leukemia.