METTL3 and acute myeloid leukemia: Furthermore, METTL3-overexpressing AML cells markedly increased the size of the spleen (Supplementary Figs. S4B and S5E) and exhibited greater infiltration into the live (Supplementary Figs. S4E and S5F) after IDA treatment than after PBS treatment, whereas the METTL3-CD group did not exhibit these phenomena.