Then, we proved that the effects of METTL3 on promoting the migration and adhesion (Fig. 6B and Supplementary Fig. S9I) and chemoresistance of AML cells (Fig. 6C and Supplementary Fig. S9H) could be reduced by an ITGA4 inhibitor (TR-14035) [36, 37]. Here, ITGA4 is linked to acute myeloid leukemia.