Indeed, PROM1-deficiency leads to the prevention of glucagon-induced gluconeogenesis via inactivating the function of radixin as A kinase-anchoring protein (AKAP)26, and aggravation of bile duct ligation (BDL)-induced liver fibrosis via SMAD7 degradation27, indicating that PROM1 has different functions in the liver. This evidence concerns the gene RDX and Hepatic fibrosis.