In tumor tissues with a high SIGLEC1/CD68 ratio, there was an increase in the infiltration and function of cytotoxic lymphocytes, based on the expression of the T cell receptor CD3 complex subunit (CD3E), natural cytotoxicity receptor (NCR1), and interferon gamma (IFNG) (Fig. 1b). The gene discussed is SIGLEC1; the disease is neoplasm.