IFN-γ producing tumor-infiltrated T cells were reduced in CD169-DTR mice, although the total number of infiltrating CD45+ immune cells was comparable with WT mice (Fig. 4g and Supplementary Fig. 4g, h) and IFN-γ producing T cells in the spleen were slightly increased (Supplementary Fig. 4i, j). The gene discussed is IFNG; the disease is neoplasm.