Blockade of NOTCH-activation by GSI treatment induced a significant downregulation of HES1 and HEY1 (Supplementary Fig. 4b) and upregulation of HLA-DR in NOTCH1-mutated CLL, supporting that NOTCH1 can repress the expression of HLA-genes (Fig. 4c). Here, NOTCH1 is linked to B-cell chronic lymphocytic leukemia.