Gene Set Enrichment Analysis (GSEA) of these differentially expressed (DE) genes identified gene clusters in canonical Notch-signaling (e.g., HES4, SEMA7A, CD300A, and DTX1), B-cell activation/ BCR-signaling (e.g., FYN, BLNK, and CR2) and MAPK-activation (e.g., MAPK8 and MAP2K6), in keeping with previous reports based on the ectopic expression of NOTCH1 in lymphoma cell lines19,20. The gene discussed is NOTCH1; the disease is lymphoma.