In this view, PVT1 and CypB may be important mediator that connects obesity and inflammation with constitutively activation of STAT3 in CRC cells and this new CypB/STAT3/PVT1 feedback loop may contribute to an improved understanding of inflammatory signaling in colorectal carcinogenesis during obesity. This evidence concerns the gene PPIB and obesity due to melanocortin 4 receptor deficiency.