In this study, we investigated roles of HFD-induced CypB in regulation of proliferation and metastasis of CRC, and identified an IL-6-triggered circuit involving STAT3-mediated transcription of PVT1 and its binding-partner CypB which facilitates STAT3 activation, connecting chronic inflammation with colorectal carcinogenesis and metastasis. The gene discussed is STAT3; the disease is colorectal carcinoma.