To investigate the function of PVT1 with regards to CRC cell growth, HCT116 and SW620 cells were infected with PVT1 shRNAs, while Caco-2 and SW480 cells were infected with overexpressing vectors, and PVT1 expression was confirmed by qRT-PCR (Fig. 5A). Here, PVT1 is linked to colorectal carcinoma.