GO analysis showed that CypB-binding RNAs were enriched in pathways of endoplasmic reticulum stress, apoptotic signaling and actin filament organization (Fig. 4A, B, Supplementary Fig. S2B–D), which are essential in tumor growth, survival and metastasis [27], indicating that CypB-binding lncRNAs may be involved in CypB’s oncogenic roles in CRC. This evidence concerns the gene PPIB and neoplasm.