Regarding the role of PC in energy metabolism, ATP production is increased in response to elevated PC expression, and given that ATP is a frequent phosphate donor for different protein kinases [35], we speculated that PC might affect tumor progression and the expression of iodine metabolism-related genes and iodine uptake in TC cells by accelerating tumor energy metabolism to increase ATP production and activate the MAPK/ERK signaling pathway. Here, MAPK1 is linked to neoplasm.