Older adults with T2DM may have significant alterations in body fluids due to coexisting diabetes related complications (such as heart failure [24]), therapeutic agents [such as thiazolidinediones [25], insulin [26] and sodium-glucose cotransporter-2 (SGLT-2) inhibitors [27] among others] and direct effects of hyperglycemia [28], which may potentially affect the validity of body composition assessment using BIA. The gene discussed is SLC5A2; the disease is heart failure.