In previous studies, we identified a dysregulation of a large number of miRNAs of the Dlk1-Dio3 cluster (DD-miRNAs) in the serum of the GRMD dog, a model for DMD (Jeanson-Leh et al, 2014), and in the plasma of DMD patients (Amor et al, 2021). The gene discussed is DIO3; the disease is Duchenne muscular dystrophy.