GPC3 and hepatocellular carcinoma: Another scFv antibody, HS20, inhibits the proliferation of hepatocellular carcinoma (HCC) cells in vitro and in vivo by binding to the HS chains of glypican-3 to block Wnt3a/β-catenin signaling, which recognizes HS structures containing IdoA2S and GlcNS6S (18, 19, 20).