In particular, polymorphisms of DNA repair genes such as ERCC1 [16], ERCC2 (XPD) [17], XRCC1 [18], XRCC3 [18], XRCC4 [19], XRCC5, XRCC6 [20], XRCC7 [21], MGMT [22], CHAF1 [23], LIG4 [19], and GLTSCR1 [17] have been associated with glioma risk [24, 25]. The gene discussed is XRCC3; the disease is central nervous system cancer.