In the ethnicity-based subgroup analysis, we again found a statistically significant association between XRCC3 p.Thr241Met and increased glioma risk in the homozygous (OR = 1.704, 95% CI = 1.358–2.317, P<0.001) and recessive models (OR = 1.305, 95% CI = 1.140–1.493, P<0.001) in the Asians (Table 2). This evidence concerns the gene XRCC3 and glioma.