In addition, although we tried to clarify whether CD68-positive cells or granulated eosinophils were associated with the reduction of tight junction proteins such as claudin-1, ZO-1, and occludin in the duodenum, CD68-positive cells and granulated eosinophils were not associated with tight junctions in the duodenum of patients with FD-P. This evidence concerns the gene CLDN1 and Fabry disease.