Anti-chromtin antibodies are also detected in SLE [38].Anti-histone antiboides target the protein components of nucleosomes and are common in SLE [39, 40], drug-indued lupus [41] and systemic sclerosis [42], Anti-LC1, liver cytosol type 1, antibodies are present in type 2 autoimmune liver disease [43], anti-glycoprotein 1 is an anti-phospholipid syndrome antibody which is associdated with increased risk of thrombosis [44], anti-SRP, signal recognition particle, has been reported in cases of necrotizing myopathy. This evidence concerns the gene UCN2 and systemic sclerosis.