CD160, CD244, CD274, CSF1R, CTLA4, HAVCR2, IDO1, IL10, KDR, LAG3, LGALS9, PDCD1, PDCD1LG2, TGFB1, TGFBR1, and TIGIT) (Fig 3) and 35 immunostimulators (C10orf54, CD27, CD28, CD40, CD40LG, CD48, CD70, CD80, CD86, CD276, CXCL12, CXCR4, ENTPD1, HHLA2, ICOS, IL2RA, IL6, IL6R, KLRC1, KLRK1, LTA, PVR, TNFRSF4, TNFRSF8, TNFRSF9, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF25, TNFSF4, TNFSF13, TNFSF13B, and TNFSF14) (Fig 4) that were closely correlated with FABP4 expression in COAD. The gene discussed is TIGIT; the disease is colon adenocarcinoma.