For example, gene expression studies have identified differential expression of chemokine (C‐X‐C motif) receptor 2 (CXCR2); alkaline phosphatase isozyme (ALPL); Charcot‐ Leyden crystal protein (CLC); carboxypeptidase A3 (CPA3); deoxyribonuclease I‐like3 (DNASEIL3) and IL‐1β (IL1B) in asthma pathogenesis [14, 15]. This evidence concerns the gene CLC and asthma.