Furthermore, immunohistochemistry (IHC)-based CMS of CRC, according to immunostaining of five oncogenic proteins (caudal type homeobox 2 (CDX2), FERM domain containing 6 (FRMD6), 5-hydroxytryptamine receptor 2B (HTR2B), zinc finger e-box binding homeobox 1 (ZEB1), and keratin (KER)), was reported by Trinh et al. in 2017. The gene discussed is FRMD6; the disease is colorectal carcinoma.