As a cancer suppressor, METTL14 inhibited the progression of colorectal malignancies by modulating the processing of m6A‐dependent primary miR‐37528; m6A modification of circORC5 mediated by METTL14 suppressed the progression of gastric malignancies by regulating the miR‐30c‐2‐3p/AKT1S1 axis29; METTL14 can suppress proliferation and metastasis of colorectal cancer by downregulating oncogenic long non‐coding RNA XIST30; and the metastatic potential of hepatocellular carcinoma was suppressed by METTL14 by modulating the processing of primary microRNA, which is dependent on m6A.31 This evidence concerns the gene AKT1S1 and hepatocellular carcinoma.