Since almost all enzymes of the glycolytic cascade are regulated by HIF-1 (29), the principal regulator of the transcriptional response to hypoxia, as well as by MYC (30), a vital regulator of metabolic reprogramming in both normal cells and cancer cells (31), we hypothesized that HIF-1 and MYC might mediate the upregulation of glycolytic genes in OIR microglia. The gene discussed is MYC; the disease is cancer.